• Partial suppression of the cot

  2021-03-12

  

  Partial suppression of the cot-1 (ts) phenotype by deletion of gul-1 has been well documented (Seiler et al., 2006). This is now also very clearly evident in the transcriptional profile of the various strains (Fig. 2). Furthermore, the comparative analysis of the single and double mutants revealed,

• Materials and methods br Results br Discussion

  2021-03-12

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial Epiberberine mg is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged in a biore

• It is well known that Doxorubicin induced cardiotoxicity

  2021-03-12

  

  It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot

• br Materials and methods br Results

  2021-03-12

  

  Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta

• As an endogenous negative modulator CRBN

  2021-03-12

  

  As an endogenous negative modulator, CRBN inhibits AMPK’s activation (phosphorylation of Thr172) by directly binding to the α-subunit of AMPK, disrupting γ-subunit recruitment to the AMPK complex (Lee et al., 2011, Lee et al., 2013). In our study, we did not focus on AMPK activation, since only a si

• E ligases provide substrate recognition specificity Ubiquiti

  2021-03-12

  

  E3 ligases provide substrate recognition specificity Ubiquitination trabectedin and substrate specificity in mammals is achieved by the existence of over six-hundred E3-ubiquitin ligases that catalyze the final step of ubiquitination, compared with only one E1 and very few E2 enzymes known till da

• br Conflicts of interest br Financial

  2021-03-12

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• Intriguingly one E residue may serve as

  2021-03-12

  

  Intriguingly, one E2 residue may serve as a molecular ‘gate’ to allow the C-terminus of ubiquitin to access the closed E2~Ub conformations favorable for ubiquitin transfer. This residue, Asp87 in UbcH5 family members, resides on one side of the opening that leads to the active site Cys (Fig. 4D). In

• Historically covalent drugs have had great success e

  2021-03-12

  

  Historically, covalent drugs have had great success (e.g., aspirin and penicillin), and covalent drugs have become a focus in anticancer and antiviral drug discovery (Kalgutkar and Dalvie, 2012, Singh et al., 2011). These compounds contain low reactivity warheads that allow covalent adducts to form

• We demonstrated that cells expressing less DHODH

  2021-03-12

  

  We demonstrated that AI-10-49 expressing less DHODH were less sensitive to DHODH inhibitors regardless of their oncogenic status. Based on the proliferation speed of cells, Kant et al. (1989), showed that slow-growing squamous cell carcinoma was more sensitive to BQR than fast-growing murine leukem

• Typical examples of CO utilization

  2021-03-12

  

  Typical examples of CO2 utilization and reduction technologies are catalytic reduction of CO2 to C1 compounds such as CO, formic acid, methanol and so on [[3], [4], [5], [6], [7], [8], [9], [10]], and catalytic organic synthesis using CO2 as a feedstock [[11], [12], [13], [14], [15], [16], [17], [18

• br Materials and methods br

  2021-03-12

  

  Materials and methods Results Discussion DDR2 played a role in cell motile behavior, but the relationship between motility and collagen activation of DDR2 tyrosine kinase was unclear. Studies with smooth muscle cells from DDR1−/− mice demonstrated a defect in cell attachment to collagen and

• br Materials and methods br Acknowledgments br

  2021-03-11

  

  Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the Dp44mT of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. The simplest of these p

• The X ray crystal structure of palbociclib bound to

  2021-03-11

  

  The X-ray crystal structure of palbociclib bound to CDK6 without a Methylpiperidino pyrazole synthesis (PDB ID: 5L2I) is very similar to that of the CDK6-cyclin V structure (Fig. 7B). However, the drug binds to the αCout conformation of monomeric CDK6 while it binds to the αCin conformation of the

• Studies have shown that the cultivation of

  2021-03-11

  

  Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem RS-1 (Liu et al., 2010, Liu et al., 2014a, Ziaei et al.,

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