• The transcription factor CREB has been extensively

  2021-02-19

  

  The transcription factor CREB has been extensively studied for its role in hippocampus-dependent learning and memory (West et al., 2002, Lonze and Ginty, 2002). Previous research has demonstrated that the phosphorylation of CREB at Ser133, performed by the ERK1/2 signaling pathway, initiates a casca

• There are five phosphorylated serines in casein However

  2021-02-18

  

  There are five phosphorylated serines in β-casein. However, only phosphorylated Ser35 was identified in the samples hydrolysed with GE at 37 and 50 °C, i.e., f32-42 and f32-44 of β-casein. The identification indicates that phosphorylated peptides were less detectable from the non-phosphorylated pept

• A An optimized BEI SEIscore based on

  2021-02-16

  

  (A) An “optimized BEI-SEIscore” based on the trends, emerged from the statistical analysis of several optimization studies in pharmaceutical industry (Abad-Zapatero, 2007, Abad-Zapatero and Blasi, 2011). This type of optimized scores has been used in many previous studies. Ki=1nM at 300° K, compare

• Several research groups have disclosed potent and

  2021-02-16

  

  Several research groups have disclosed potent and selective DGAT-1 inhibitors from several chemically-distinct series. Pre-clinical studies with these compounds have confirmed that small molecule DGAT-1 inhibitors can elicit metabolic outcomes comparable to those observed in DGAT-1−/− mice.19, 20, 2

• Several highly selective COX inhibitors coxibs have been rep

  2021-02-16

  

  Several highly selective COX-2 inhibitors (coxibs) have been reported and marketed [6], including celecoxib [7] and etoricoxib [8] (Fig. 1). Even though these drugs produce less ulceration than conventional NSAIDs, coxibs still produce significant gastric and cardiovascular side effects due to the d

• The aim of the present study was to

  2021-02-15

  

  The aim of the present study was to investigate the acute effects of THC on resting state 8-Azido-ATP neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharmacological MRI study. A

• The dermal ECM also shows

  2021-02-15

  

  The dermal ECM also shows specificities. During zebrafish embryogenesis, the epidermis is composed of the outer periderm and the inner basal keratinocytes, which are responsible for the initial deposition of ECM in the primitive acellular dermis [17].The dermal endothelial cells, a species-specific

• Ginsenoside Re lysine mixture had increased anticancer effec

  2021-02-12

  

  Ginsenoside Re-lysine mixture had increased anticancer effects upon heat processing by regulating Bcl-2 and Bax (Yamabe et al., 2013). Ginsenoside Re (20mg/kg) inhibited NF-κB activation by inhibiting LPS binding to TLR4 on macrophages in TNBS-treated mice (Lee, Hyam, Jang, Han, & Kim, 2012). The ch

• fexofenadine hydrochloride receptor Because macrophages clea

  2021-02-12

  

  Because macrophages clear the injured tissue of dead fexofenadine hydrochloride receptor and matrix debris, macrophage infiltration is essential for normal tissue repair. In cardiac remodeling by MI, however, macrophages infiltrate excessively into not only the infarct area and marginal area of MI.

• DGK is a key enzyme in glucose uptake

  2021-02-12

  

  DGKδ is a key enzyme in glucose uptake in skeletal muscle. Chibalin et al. demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Additionally, DGKδ expression was increased in people who exhibited enhanced insulin sensitivity after exercise training [56]. Fr

• br Materials and methods br Results br Discussion

  2021-02-12

  

  Materials and methods Results Discussion Our previous investigation demonstrated that some genes in the latex that were involved in rubber biosynthesis were regulated by exogenous JA, and Hbvp1 is one of the JA-responsive genes in the latex of rubber trees [23]. In this study, the Hbvp1 enc

• br Materials and methods br Results br Discussion In this

  2021-02-12

  

  Materials and methods Results Discussion In this study we characterized in more detail the interrelationship between the expression levels of the B. malayi Bm-cpl-3 and Bm-cpl-6 cysteine proteases and the fitness of Wolbachia, and consequently that of the parasite. Our present in vitro data

• Introduction Cysteinyl leukotrienes CysLTs LTC LTD and

  2021-02-11

  

  Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic BIX 02565 and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranlukast [3], [4] and montelukas

• Liver metabolic programming begins in utero Aiming

  2021-02-11

  

  Liver metabolic programming begins in utero. Aiming to find a reason for the decreased lipid catabolism enzyme expression observed in fetuses and offspring from SFD rats, we studied the effect of leptin on liver catabolism in fetuses from control and SFD rats. Livers from control fetuses responded t

• Park et al expanded their own model

  2021-02-11

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino Bromfenac Sodium solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausnitz [3

15846 records 686/1057 page Previous Next First page 上5页 686687688689690 下5页 Last page