• Common and rare SCN A variants may contribute to

  2019-06-10

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• The increasing burden of NCDs poses

  2019-06-10

  

  The increasing burden of NCDs poses an enormous threat to populations and health systems across the globe. The Sustainable Development Goals represent an important opportunity to integrate efforts to reduce the burden of NCDs and promote sustainable development. The recent identification of NCDs as

• What would mitigation strategies to deal

  2019-06-10

  

  What would mitigation strategies to deal with future pandemic risks of zoonotic disease look like? Analyses of emerging disease trends during the past six decades have shown that Ebola fits the ml to moles calculator pattern. This pattern involves zoonotic spillover from wildlife or livestock drive

• En ella se muestran los criterios sobre los que

  2019-06-10

  

  En ella se muestran los criterios sobre los que se acepta negociar en los diálogos de paz en La Habana. Fuera de estas reglas de juego para la negociación, se establecen puntos en común en ella y que según Aira: “Es indiscutible que el ‘Poder’ desempeña un papel fundamental dentro de la negociación”

• But in comes the good news from these three

  2019-06-10

  

  But in comes the good news from these three NEOVITA studies: there are other effective, feasible interventions that can be implemented everywhere. Rajiv Bahl and colleagues identify that early initiation of breastfeeding and exclusive breastfeeding have independent beneficial effects on neonatal mo

• Conflicts of interest br Introduction Hepatocellular carcino

  2019-06-10

  

  Conflicts of interest Introduction Hepatocellular carcinoma (HCC) is one of the most common cancers and is the second leading cause of cancer death worldwide. In 2012, 782,500 new HCC cases and 745,500 deaths were caused by this persistent disease worldwide, with about 50% of the total number of

• Introduction Osteosarcoma OS is the most common type of bone

  2019-06-10

  

  Introduction Osteosarcoma (OS) is the most common type of bone tumor occurred in adolescents and children [1]. OS is highly malignant and accounts for about half of bone sarcomas with high potential of metastasis [2]. Treatment for OS is mainly depended on surgical operation, assisted with chemothe

• br Benefits and tips for

  2019-06-06

  

  Benefits and tips for antitachycardia pacing To reduce ICD shocks, antitachycardia pacing (ATP) for terminating lethal ventricular tachyarrhythmias must be programmed. There are 2 main types of ATP: burst (scan) pacing and autodecremental overdrive pacing (ramp pacing). Programming ATP is common

• br Methods br Results br Discussion br Conclusions br

  2019-06-06

  

  Methods Results Discussion Conclusions Author contributions Disclosures and funding sources Conflicts of interest Introduction Head-up tilt (HUT) testing has become a widely accepted diagnostic tool for the evaluation of neurally mediated syncope (NMS), which is a major cause

• br Practical use of the

  2019-06-06

  

  Practical use of the Sweet Tip™ screw-in lead Entrapment of screw-in lead Entrapment is a relatively rare complication that can occur with the Sweet Tip™ screw-in lead as often as with other types of leads [13,14]. In the Sweet Tip™ lead, the helix might become exposed in the atrium and the ri

• br Implementation of a programme called the the key componen

  2019-06-05

  

  Implementation of a programme called the , the key component of the UNICEF/WHO Baby-Friendly Hospital Initiative (BFHI) increases exclusive breastfeeding at 3 months, any breastfeeding at 12 months, and reduces diarrhoeal disease. These outcomes were shown in a cluster-randomised study of 31 hospi

• br Discussion We successfully prevented the initiation of AF

  2019-06-05

  

  Discussion We successfully prevented the initiation of AF without inhibiting the AF-triggering APB, and eliminated the AF-triggering APB located close to the sinus node without damage to sinus node function. Nifekalant is an IKr antagonist that prolongs the duration of myocardial wnt inhibitor a

• There are several shortcomings to this study that

  2019-06-05

  

  There are several shortcomings to this study that need to be considered. The small size of this series is an obvious shortcoming. Due to the relative rarity of the disease, this problem is not unique to this series and authors of a recent meta-analysis noted the small sample size of other studies as

• heat shock protein inhibitors br We have reviewed the issues

  2019-06-01

  

  We have reviewed the issues and arguments presented by Wang et al. In fact, we have well-clarified these issues in “Discussion” section of our original article. The aim of our study was to investigate the expression of maternal antineuronal heat shock protein inhibitors and their role in childho

• br La difusi n en Espa a de

  2019-06-01

  

  La difusión en España de la Música práctica, impresa en Boloña en 1482 y escrita originalmente en latín, no sólo es innegable, sino decisiva ginsenoside rg3 lo largo del siglo xvi. Francisco Salinas es un firme defensor de las teorías de Ramos Pareja y, sobre todo, toma su partido en relación con

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