• The highly conserved homeobox gene NKX

  2018-10-24

  

  The highly conserved homeobox gene NKX2-5 is expressed from the cardiac crescent stage of heart development and is maintained in the myocardial lineages throughout life (Harvey, 1996). Therefore, NKX2-5 expression can be used to isolate cardiac progenitors, immature cardiomyocytes and mature cardiom

• We herein show that simple

  2018-10-24

  

  We herein show that simple supplementation with doxycycline greatly improves both hESC/iPSC viability and self-renewal. In practice, doxycycline dramatically enhances hESC/iPSC expandability, and the effects continue for long time periods. The effects of doxycycline are mediated by direct activation

• br Mitochondrial replacement therapy Because of

  2018-10-24

  

  Mitochondrial replacement therapy Because of the uniparental, and usually maternal mode of mitochondrial inheritance diseases caused by mitochondria dysfunction are propagated from mother to offspring in a “dominant” manner. Mitochondrial replacement therapy, which involves transfer of a maternal

• br Results br Discussion Frequent tumor relapse in multiple

  2018-10-24

  

  Results Discussion Frequent tumor relapse in multiple tumor types has now been attributed to the presence of residual CSCs after conventional treatments. We and others have previously identified CD133 to mark a liver CSC subpopulation in HCC (Ma et al., 2007, 2010). Yet, the functional paths b

• These studies add to a growing body

  2018-10-24

  

  These studies add to a growing body of information related to the role of p38 MAPK signaling in skeletal muscle progenitor cells. Over a decade ago, a requirement for p38 in the regulation of rodent myoblast differentiation was defined (Cuenda and Cohen, 1999; Zetser et al., 1999). Based on these pr

• A variety of studies have compared the expression profiles

  2018-10-24

  

  A variety of studies have compared the expression profiles, pluripotentiality, and genetic and epigenetic stability of hESC and iPSC including lines generated using different strategies, distinct parental somatic cell types, or reprogramming methods (Bock et al., 2011; International Stem Cell Initia

• Others have reported both B and

  2018-10-24

  

  Others have reported both B and T cell effects after osteolineage cell deletion (Ding and Morrison, 2013) but the promoter used in some of those studies, Col1(2.3), extends through many cell stages of osteolineage progression. Here we define that these osteolineage cell states provide distinctive fu

• In addition we observed significantly elevated levels of

  2018-10-24

  

  In addition, we observed significantly elevated levels of synapsin and dopamine in Parkin cultures, although the changes in PINK1 cells did not reach statistical significance when compared with control iPSC- or ESC-derived floor-plate mDA neurons. Increased DA levels may appear, in contrast to the w

• E64 In reality though the electrode

  2018-10-24

  

  In reality, though, the electrode shapes are slightly different from the ideal ones because the last are difficult to be produced. As a consequence, the reduced dispersion, which actually depends on the working mode, is a bit smaller: D ≈ 12−13. The device has been made from copper, its E64 dimensio

• PR-619 Literacy is a fundamental resource highly correlated

  2018-10-24

  

  Literacy is a fundamental resource highly correlated with educational attainment. Broadly, literacy has been defined as using printed and written information to function in society, to achieve one’s goals, and to develop one’s knowledge and potential. Literacy enables individuals to gain knowledge a

• In our case we test if attitudes toward cut

  2018-10-24

  

  In our case, we test if attitudes toward cut and uncut girls differ between Sudanese people living in Switzerland versus Sudan. This is a test of the joint effect of selection and acculturation. We additionally analyze variation in attitudes within Switzerland, including an analysis of whether attit

• An individual can maintain various

  2018-10-24

  

  An individual can maintain various social identities simultaneously, and one will stand out among the rest when the combination of personal and situational characteristics propitiate the ‘depersonalization’ of personal identity. Depersonalization “does not insinuate a negative connotation in the sen

• People who declared to be

  2018-10-23

  

  People who declared to be non-white attend religious activities more than white people. However, this result occurs only among women who attend church less than once a month. This result is consistent with the BYL-719 raised by Azzi and Ehrenberg (1975) model which explains differences in demands f

• The MERS virus which emerged in is now considered a

  2018-10-23

  

  The MERS virus, which emerged in 2012, is now considered a threat to global public health. Developing an effective vaccine is important to control MERS-CoV infection. To date, virus-vector vaccines, such as recombinant modified vaccinia virus Ankara (MVA), which expresses full-length MERS-CoV spike

• CART models identified the most important predictors

  2018-10-23

  

  CART models identified the most important predictors of mortality as duration of therapy or follow-up (importance score=100%), CD4+ T cell counts (score=47%), TTP (score=38%), and age (score=21%). The identified thresholds (which partitioned patients to homogenous groups with similar mortality risk)

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