• Our previous studies have demonstrated that the DDR discoidi

  2020-08-06

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• With respect to CYP A the Kaempferia parviflora

  2020-08-06

  

  With respect to CYP1A2, the Kaempferia parviflora extract presented a mixed-type interaction pattern with an increase in both Vmax and Km suggesting that it might bind to both the active site of the enzyme and an allosteric site. Interference with the allosteric site of CYP1A2 could modify the confo

• The histologic finding that EBV infected B

  2020-08-06

  

  The histologic finding that EBV-infected Propylthiouracil in infectious mononucleosis tend to avoid the GCs and instead accumulate under the epithelium of certain mucosal tissues34, 129 could be explained by the above-mentioned expression patterns of chemokine receptors on EBV-infected B cells. CXCR

• br STAR Methods br Author Contributions

  2020-08-06

  

  STAR★Methods Author Contributions Z.Z., H.G., and C.Y. conceived the project. C.Y. performed almost all experiments. H.G. performed all bioinformatics and statistical analysis. H.G. and J.H. performed some of the experiments. S.D. performed the in vitro DNA replication experiments under the gu

• A number of studies have been

  2020-08-06

  

  A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key Eptifibatide of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidopsis thal

• In conclusion by investigating the cysteine protease transcr

  2020-08-06

  

  In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070

• Our study using real time confocal microscopy

  2020-08-06

  

  Our study using real-time confocal microscopy in live Cryptochlorogenic acid provides the first evidence that the human CRF2(a) receptor activated by UCN2 or UCN3 rapidly and strongly recruits GFP-labeled βarrestin2 to the plasma membrane where βarrestin2 proteins colocalize with CRF2(a) receptor p

• br Transparency document br Introduction Nanosecond

  2020-08-06

  

  Transparency document Introduction Nanosecond electric pulses (nsEP) evoke a high voltage in specific cellular structures without producing any heat, thereby triggering responses such as membrane poration and DNA damage [1], [2], [3]. nsEP can be used to enhance chemotherapy and ablate tissues

• The approach we take here is designed to

  2020-08-06

  

  The approach we take here is designed to capture sharp discontinuities in the intensity surface that result from qualitative yet unavailable covariates or environmental conditions as the one seen in this example. Further examples where this approach could be important is ecological data with several

• Several groups focused on the

  2020-08-05

  

  Several groups focused on the expression of EBI2 and of the ligand generating enzymes in astrocytes and macrophages and showed that both cell types express EBI2 as well as the enzymes producing its ligand [[39], [40], [41], [42]]. Furthermore, EBI2 triggering via 7α,25-OHC in astrocytes was shown to

• The synthesis of the aziridine started

  2020-08-05

  

  The synthesis of the aziridine () started with -aspartic INCB024360 analogue synthesis as chiral building block. Methylation of the carboxylic acids followed by the introduction of the required sulfonamide yields the diester . The diester was then reduced to reveal diol which underwent selective

• Prostaglandins PGs are lipid mediators that exhibit a variet

  2020-08-05

  

  Prostaglandins (PGs) are lipid mediators that exhibit a variety of physiological properties by interacting specific G protein-coupled receptors (GPCRs) [10]. PGD2 is synthesized from PGH2 through two distinct PGD synthases; lipocalin-type PGD synthase (L-PGDS) and hematopoietic PGD synthase (H-PGDS)

• MTX is a major component of the

  2020-08-05

  

  MTX is a major component of the curative treatment of childhood ALL, and the extent of accumulation of its active polyglutamates (MTXPG) determines its cytotoxicity and influences treatment response in childhood ALL. GGH converts long-chain MTXPG into shorter-chain MTXPG and ultimately into MTX, whi

• br Conclusion In summary we provided evidence that spinal co

  2020-08-05

  

  Conclusion In summary, we provided evidence that spinal cord injury animals do develop mechanical allodynia as well as an upregulation of mainly ETAR after spinal cord injury that are associated with the pain processing. Thus, endothelial receptors antagonists might constitute an attractive pharm

• br Methods br Results Main characteristics of study populati

  2020-08-05

  

  Methods Results Main characteristics of study population are presented in Table 1. AD cases had higher co-morbidity score and lower socioeconomic position than controls. Women with AD had undergone any surgery (unilateral/bilateral oophorectomy, hysterectomy, hysterectomy with bilateral oophor

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